Investigators dedicated to researching Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS) from around the United States have come together to create critical resources for the HSP and PLS community. The SP-CERN (Spastic Paraplegia Centers of Excellence Research Network) establishes a network of ten initial centers in North America. These centers bring together established physician-scientists and their multidisciplinary teams. SP-CERN will support the development of a registry and natural history study across all ages, a biobank for research biospecimens, and a genomic archive. These efforts will lay the groundwork for numerous opportunities to improve diagnosis and clinical trial readiness. Our objective is to harmonize this effort with similar consortia in Canada, Europe, Asia, and South America to accelerate basic and clinical research on HSP and PLS globally. SP-CERN will provide critical research infrastructure for collaborative, high-quality research on HSP and PLS in North America and beyond.